Drug interactions
Insulin degludec-liraglutide + Timolol
Severity: Moderate
Insulin degludec-liraglutide and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic timolol can prolong hypoglycemia and mask its warning symptoms in insulin-treated patients. Ophthalmic use gives lower but possible systemic exposure.
What this interaction means in plain words
Insulin degludec-liraglutide and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Timolol belongs to Cardiovascular.
Why it happens
Non-selective beta-blockade impairs glycogenolysis and masks adrenergic symptoms.
What to do
Monitor blood glucose when timolol is started, including as eye drops. Counsel patients about masked hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Insulin degludec-liraglutide with Timolol?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic timolol can prolong hypoglycemia and mask its warning symptoms in insulin-treated patients. Ophthalmic use gives lower but possible systemic exposure.
How serious is the interaction between Insulin degludec-liraglutide and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when timolol is started, including as eye drops. Counsel patients about masked hypoglycemia symptoms.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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