Drug interactions
Insulin degludec-liraglutide + Trandolapril
Severity: Moderate
Insulin degludec-liraglutide and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and have been linked to hypoglycemia in patients taking insulin or other antidiabetic agents. The risk is greatest in the first weeks after the ACE inhibitor is started.
What this interaction means in plain words
Insulin degludec-liraglutide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Trandolapril belongs to Cardiovascular.
Why it happens
Enhanced insulin sensitivity, possibly through increased bradykinin activity, adds to the glucose-lowering effect of insulin and liraglutide.
What to do
Monitor blood glucose more often when starting trandolapril, especially in the first month. Lower the insulin dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Insulin degludec-liraglutide with Trandolapril?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and have been linked to hypoglycemia in patients taking insulin or other antidiabetic agents. The risk is greatest in the first weeks after the ACE inhibitor is started.
How serious is the interaction between Insulin degludec-liraglutide and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when starting trandolapril, especially in the first month. Lower the insulin dose if hypoglycemia develops.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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