Drug interactions
Insulin detemir + Procarbazine
Severity: Moderate
Insulin detemir and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has monoamine oxidase inhibiting properties, and MAO inhibitors have been associated with enhanced blood glucose lowering in patients treated with insulin. Hypoglycemia may be more frequent or prolonged.
What this interaction means in plain words
Insulin detemir and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin detemir belongs to Endocrine; Procarbazine belongs to Oncology.
Why it happens
Weak MAO inhibition may enhance insulin secretion or sensitivity and impair counter-regulation, adding to insulin's glucose-lowering effect; the mechanism is not firmly established.
What to do
Monitor blood glucose more frequently when procarbazine is started or stopped. Reduce the insulin detemir dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Insulin detemir with Procarbazine?
MediHelp rates the interaction as moderate. Insulin detemir and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has monoamine oxidase inhibiting properties, and MAO inhibitors have been associated with enhanced blood glucose lowering in patients treated with insulin. Hypoglycemia may be more frequent or prolonged.
How serious is the interaction between Insulin detemir and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when procarbazine is started or stopped. Reduce the insulin detemir dose if hypoglycemia occurs.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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