Drug interactions
Insulin detemir + Tolazamide
Severity: Moderate
Insulin detemir and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonylureas combined with insulin have additive glucose-lowering effects and a clearly increased risk of hypoglycemia, which can be prolonged with long-acting sulfonylureas.
What this interaction means in plain words
Insulin detemir and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin detemir belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect: the sulfonylurea stimulates pancreatic insulin release while insulin detemir supplies exogenous insulin.
What to do
Monitor blood glucose closely when starting, stopping or changing doses, and reduce the sulfonylurea or insulin dose if hypoglycemia occurs. Educate the patient on hypoglycemia recognition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Insulin detemir with Tolazamide?
MediHelp rates the interaction as moderate. Insulin detemir and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonylureas combined with insulin have additive glucose-lowering effects and a clearly increased risk of hypoglycemia, which can be prolonged with long-acting sulfonylureas.
How serious is the interaction between Insulin detemir and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting, stopping or changing doses, and reduce the sulfonylurea or insulin dose if hypoglycemia occurs. Educate the patient on hypoglycemia recognition.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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