Drug interactions
Insulin glargine-lixisenatide + Nortriptyline
Severity: Minor
Insulin glargine-lixisenatide and Nortriptyline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants have been associated with enhanced glucose lowering and hypoglycemia in patients on antidiabetic drugs. The effect is variable and usually small.
What this interaction means in plain words
Insulin glargine-lixisenatide and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin glargine-lixisenatide belongs to Endocrine; Nortriptyline belongs to Central Nervous System.
Why it happens
The mechanism is not well established; tricyclics may affect insulin sensitivity and glucose metabolism, producing an additive effect.
What to do
Monitor blood glucose when nortriptyline is started or stopped and adjust the antidiabetic dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Nortriptyline?
MediHelp rates the interaction as minor. Insulin glargine-lixisenatide and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants have been associated with enhanced glucose lowering and hypoglycemia in patients on antidiabetic drugs. The effect is variable and usually small.
How serious is the interaction between Insulin glargine-lixisenatide and Nortriptyline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when nortriptyline is started or stopped and adjust the antidiabetic dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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