Drug interactions
Insulin glargine-lixisenatide + Pasireotide
Severity: Major
Insulin glargine-lixisenatide and Pasireotide: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide strongly suppresses insulin secretion and incretin response and commonly causes hyperglycemia, which can counteract insulin glargine and lixisenatide. Diabetes control may worsen markedly.
What this interaction means in plain words
Insulin glargine-lixisenatide and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin glargine-lixisenatide belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Somatostatin receptor activation inhibits insulin and incretin secretion, causing pharmacodynamic antagonism.
What to do
Monitor glucose closely when starting pasireotide and intensify antidiabetic therapy as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Pasireotide?
MediHelp rates the interaction as major. Insulin glargine-lixisenatide and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pasireotide strongly suppresses insulin secretion and incretin response and commonly causes hyperglycemia, which can counteract insulin glargine and lixisenatide. Diabetes control may worsen markedly.
How serious is the interaction between Insulin glargine-lixisenatide and Pasireotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely when starting pasireotide and intensify antidiabetic therapy as needed.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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