Drug interactions
Insulin glargine-lixisenatide + Phenelzine
Severity: Moderate
Insulin glargine-lixisenatide and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Monoamine oxidase inhibitors such as phenelzine can enhance insulin-induced hypoglycemia and have caused hypoglycemic episodes in diabetic patients. Hypoglycemia may be more frequent or prolonged.
What this interaction means in plain words
Insulin glargine-lixisenatide and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Phenelzine belongs to Central Nervous System.
Why it happens
MAOIs may increase insulin secretion and sensitivity and impair counter-regulation; the exact mechanism is not fully established.
What to do
Monitor blood glucose frequently when phenelzine is started or stopped. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Phenelzine?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Monoamine oxidase inhibitors such as phenelzine can enhance insulin-induced hypoglycemia and have caused hypoglycemic episodes in diabetic patients. Hypoglycemia may be more frequent or prolonged.
How serious is the interaction between Insulin glargine-lixisenatide and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when phenelzine is started or stopped. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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