Drug interactions
Insulin glargine-lixisenatide + Pioglitazone
Severity: Moderate
Insulin glargine-lixisenatide and Pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone adds to the glucose-lowering effect of insulin and lixisenatide, increasing the risk of hypoglycemia. The combination of a thiazolidinedione with insulin also increases fluid retention, edema and the risk of heart failure.
What this interaction means in plain words
Insulin glargine-lixisenatide and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Pioglitazone belongs to Endocrine.
Why it happens
Additive glucose lowering through insulin sensitization plus exogenous insulin; both thiazolidinedione and insulin promote renal sodium and fluid retention.
What to do
Monitor glucose and reduce the insulin dose if hypoglycemia occurs. Watch for weight gain, edema and heart failure signs, and avoid in patients with symptomatic heart failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Pioglitazone
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Pioglitazone?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pioglitazone adds to the glucose-lowering effect of insulin and lixisenatide, increasing the risk of hypoglycemia. The combination of a thiazolidinedione with insulin also increases fluid retention, edema and the risk of heart failure.
How serious is the interaction between Insulin glargine-lixisenatide and Pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and reduce the insulin dose if hypoglycemia occurs. Watch for weight gain, edema and heart failure signs, and avoid in patients with symptomatic heart failure.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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