Drug interactions
Insulin glargine-lixisenatide + Propranolol
Severity: Moderate
Insulin glargine-lixisenatide and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol can mask adrenergic warning signs of hypoglycemia such as tremor and tachycardia, and delay recovery of normal glucose after insulin-induced hypoglycemia. Sweating may remain as a symptom. It can also modestly worsen glucose tolerance.
What this interaction means in plain words
Insulin glargine-lixisenatide and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Propranolol belongs to Cardiovascular.
Why it happens
Nonselective beta-blockade blunts catecholamine-mediated hypoglycemia symptoms and glycogenolysis, and reduces insulin secretion.
What to do
Monitor blood glucose more frequently and educate the patient that symptoms may be masked. Consider a cardioselective beta-blocker if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Propranolol?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol can mask adrenergic warning signs of hypoglycemia such as tremor and tachycardia, and delay recovery of normal glucose after insulin-induced hypoglycemia. Sweating may remain as a symptom. It can also modestly worsen glucose tolerance.
How serious is the interaction between Insulin glargine-lixisenatide and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently and educate the patient that symptoms may be masked. Consider a cardioselective beta-blocker if one is needed.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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