Drug interactions
Insulin glargine-lixisenatide + Somatrogon
Severity: Moderate
Insulin glargine-lixisenatide and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone analogs can reduce insulin sensitivity and raise blood glucose, especially at higher doses. In patients on insulin glargine-lixisenatide, glycemic control may worsen after somatrogon is started.
What this interaction means in plain words
Insulin glargine-lixisenatide and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Growth hormone induces insulin resistance, which opposes the glucose-lowering action of insulin and GLP-1 agonists.
What to do
Monitor blood glucose more frequently when somatrogon is started or its dose changed. Adjust the insulin glargine-lixisenatide dose if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Somatrogon?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone analogs can reduce insulin sensitivity and raise blood glucose, especially at higher doses. In patients on insulin glargine-lixisenatide, glycemic control may worsen after somatrogon is started.
How serious is the interaction between Insulin glargine-lixisenatide and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when somatrogon is started or its dose changed. Adjust the insulin glargine-lixisenatide dose if hyperglycemia develops.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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