Drug interactions
Insulin glargine-lixisenatide + Timolol
Severity: Moderate
Insulin glargine-lixisenatide and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic timolol, like other nonselective beta-blockers, can mask hypoglycemia symptoms and delay glucose recovery after insulin-induced hypoglycemia. It may also modestly impair glucose tolerance. Ophthalmic timolol has lower but non-zero systemic exposure.
What this interaction means in plain words
Insulin glargine-lixisenatide and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Timolol belongs to Cardiovascular.
Why it happens
Nonselective beta-blockade blunts adrenergic hypoglycemia symptoms and glycogenolysis, and reduces insulin secretion.
What to do
Monitor blood glucose more often and counsel the patient that warning symptoms may be masked. Consider a cardioselective agent if a beta-blocker is needed systemically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Timolol?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic timolol, like other nonselective beta-blockers, can mask hypoglycemia symptoms and delay glucose recovery after insulin-induced hypoglycemia. It may also modestly impair glucose tolerance. Ophthalmic timolol has lower but non-zero systemic exposure.
How serious is the interaction between Insulin glargine-lixisenatide and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often and counsel the patient that warning symptoms may be masked. Consider a cardioselective agent if a beta-blocker is needed systemically.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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