Drug interactions
Insulin glulisine + Isocarboxazid
Severity: Moderate
Insulin glulisine and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Monoamine oxidase inhibitors can enhance the glucose-lowering effect of insulin and may increase the frequency or severity of hypoglycemia. Mealtime insulin doses may therefore need to be lowered.
What this interaction means in plain words
Insulin glulisine and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glulisine belongs to Endocrine; Isocarboxazid belongs to Central Nervous System.
Why it happens
MAOIs may augment insulin secretion or sensitivity and impair counter-regulatory responses, producing additive hypoglycemia; the exact mechanism is not fully established.
What to do
Monitor blood glucose more frequently when starting, stopping or changing the MAOI dose. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Insulin glulisine
Frequently asked questions
Can I take Insulin glulisine with Isocarboxazid?
MediHelp rates the interaction as moderate. Insulin glulisine and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Monoamine oxidase inhibitors can enhance the glucose-lowering effect of insulin and may increase the frequency or severity of hypoglycemia. Mealtime insulin doses may therefore need to be lowered.
How serious is the interaction between Insulin glulisine and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, stopping or changing the MAOI dose. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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