Drug interactions
Insulin glulisine + Metformin-repaglinide
Severity: Moderate
Insulin glulisine and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rapid-acting insulin glulisine combined with metformin and repaglinide produces additive blood glucose lowering. The risk of hypoglycemia is increased, particularly around meals when repaglinide and mealtime insulin act together.
What this interaction means in plain words
Insulin glulisine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glulisine belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose-lowering effects of exogenous insulin, repaglinide-induced insulin secretion and metformin's reduction of hepatic glucose production.
What to do
Monitor blood glucose, especially postprandially, and adjust mealtime insulin or repaglinide doses if hypoglycemia occurs. Teach the patient how to recognize and treat hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Insulin glulisine
Frequently asked questions
Can I take Insulin glulisine with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Insulin glulisine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rapid-acting insulin glulisine combined with metformin and repaglinide produces additive blood glucose lowering. The risk of hypoglycemia is increased, particularly around meals when repaglinide and mealtime insulin act together.
How serious is the interaction between Insulin glulisine and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, especially postprandially, and adjust mealtime insulin or repaglinide doses if hypoglycemia occurs. Teach the patient how to recognize and treat hypoglycemia.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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