Drug interactions
Insulin glulisine + Nateglinide
Severity: Moderate
Insulin glulisine and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide with insulin gives additive glucose lowering and a greater risk of hypoglycemia, particularly if meals are skipped.
What this interaction means in plain words
Insulin glulisine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glulisine belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect of exogenous insulin and nateglinide-stimulated pancreatic insulin secretion.
What to do
Monitor glucose and reduce the insulin or nateglinide dose if hypoglycemia occurs. Take nateglinide only with meals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Insulin glulisine with Nateglinide?
MediHelp rates the interaction as moderate. Insulin glulisine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nateglinide with insulin gives additive glucose lowering and a greater risk of hypoglycemia, particularly if meals are skipped.
How serious is the interaction between Insulin glulisine and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and reduce the insulin or nateglinide dose if hypoglycemia occurs. Take nateglinide only with meals.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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