Drug interactions
Insulin glulisine + Pasireotide
Severity: Moderate
Insulin glulisine and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide strongly suppresses insulin secretion and incretin release and frequently causes hyperglycemia, which can raise insulin requirements. Glucose may fluctuate when therapy is started, changed or stopped.
What this interaction means in plain words
Insulin glulisine and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glulisine belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: somatostatin receptor activation reduces insulin and incretin secretion.
What to do
Monitor glucose frequently, especially at initiation and after dose changes. Increase insulin glulisine as required and reduce it if pasireotide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin glulisine and Pasireotide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin glulisine
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Insulin glulisine with Pasireotide?
MediHelp rates the interaction as moderate. Insulin glulisine and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide strongly suppresses insulin secretion and incretin release and frequently causes hyperglycemia, which can raise insulin requirements. Glucose may fluctuate when therapy is started, changed or stopped.
How serious is the interaction between Insulin glulisine and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently, especially at initiation and after dose changes. Increase insulin glulisine as required and reduce it if pasireotide is stopped.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
