Drug interactions
Insulin glulisine + Somapacitan
Severity: Moderate
Insulin glulisine and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone reduces insulin sensitivity, so somapacitan may weaken the effect of insulin glulisine. Blood glucose may rise and insulin doses may need to be increased.
What this interaction means in plain words
Insulin glulisine and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glulisine belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Growth hormone induces insulin resistance, opposing insulin's glucose-lowering action.
What to do
Monitor glucose when somapacitan is started or the dose is increased and adjust the insulin glulisine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Insulin glulisine with Somapacitan?
MediHelp rates the interaction as moderate. Insulin glulisine and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces insulin sensitivity, so somapacitan may weaken the effect of insulin glulisine. Blood glucose may rise and insulin doses may need to be increased.
How serious is the interaction between Insulin glulisine and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when somapacitan is started or the dose is increased and adjust the insulin glulisine dose as needed.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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