Drug interactions
Insulin inhaled + Irbesartan
Severity: Moderate
Insulin inhaled and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers can improve insulin sensitivity, which may enhance the glucose-lowering effect of insulin. Hypoglycemia may occur, particularly when the ARB is first started.
What this interaction means in plain words
Insulin inhaled and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose lowering, probably through improved insulin sensitivity with ARB therapy; the mechanism is not firmly established.
What to do
Monitor blood glucose more often when irbesartan is started or the dose is changed. Reduce the insulin dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Insulin inhaled with Irbesartan?
MediHelp rates the interaction as moderate. Insulin inhaled and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers can improve insulin sensitivity, which may enhance the glucose-lowering effect of insulin. Hypoglycemia may occur, particularly when the ARB is first started.
How serious is the interaction between Insulin inhaled and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when irbesartan is started or the dose is changed. Reduce the insulin dose if hypoglycemia develops.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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