Drug interactions
Insulin inhaled + Levothyroxine
Severity: Moderate
Insulin inhaled and Levothyroxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone increases glucose production and metabolic turnover, so starting or increasing levothyroxine can worsen glycemic control. Insulin requirements may change as thyroid status is corrected.
What this interaction means in plain words
Insulin inhaled and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thyroid hormone increases gluconeogenesis, glycogenolysis and glucose turnover, opposing the glucose-lowering effect of insulin.
What to do
Monitor blood glucose more often when levothyroxine is started or its dose changed. Adjust the insulin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levothyroxine
Frequently asked questions
Can I take Insulin inhaled with Levothyroxine?
MediHelp rates the interaction as moderate. Insulin inhaled and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone increases glucose production and metabolic turnover, so starting or increasing levothyroxine can worsen glycemic control. Insulin requirements may change as thyroid status is corrected.
How serious is the interaction between Insulin inhaled and Levothyroxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when levothyroxine is started or its dose changed. Adjust the insulin dose accordingly.
What other medicines interact with Levothyroxine?
MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Sodium iodide i-131, Tiratricol. The full list is on the Levothyroxine page.
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