Drug interactions
Insulin isophane human / insulin regular human + Irbesartan
Severity: Moderate
Insulin isophane human / insulin regular human and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irbesartan may enhance insulin sensitivity and increase the glucose-lowering effect of insulin mixtures. This can lead to episodes of hypoglycemia, especially early in combined therapy.
What this interaction means in plain words
Insulin isophane human / insulin regular human and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible improvement in insulin sensitivity with angiotensin receptor blockade; the mechanism is not fully established.
What to do
Check glucose more frequently after starting or adjusting irbesartan. Lower the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin isophane human / insulin regular human and Irbesartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Insulin isophane human / insulin regular human with Irbesartan?
MediHelp rates the interaction as moderate. Insulin isophane human / insulin regular human and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irbesartan may enhance insulin sensitivity and increase the glucose-lowering effect of insulin mixtures. This can lead to episodes of hypoglycemia, especially early in combined therapy.
How serious is the interaction between Insulin isophane human / insulin regular human and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose more frequently after starting or adjusting irbesartan. Lower the insulin dose if hypoglycemia occurs.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
