Drug interactions
Insulin isophane protamine human + Nateglinide
Severity: Moderate
Insulin isophane protamine human and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide stimulates short-acting insulin release and together with NPH insulin increases the risk of hypoglycemia, particularly if meals are skipped.
What this interaction means in plain words
Insulin isophane protamine human and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin isophane protamine human belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive glucose lowering from meglitinide-induced endogenous insulin secretion plus exogenous insulin.
What to do
Monitor glucose closely and reduce the insulin dose if hypoglycemia occurs. Advise taking nateglinide only with meals and omitting it when a meal is skipped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Insulin isophane protamine human with Nateglinide?
MediHelp rates the interaction as moderate. Insulin isophane protamine human and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nateglinide stimulates short-acting insulin release and together with NPH insulin increases the risk of hypoglycemia, particularly if meals are skipped.
How serious is the interaction between Insulin isophane protamine human and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely and reduce the insulin dose if hypoglycemia occurs. Advise taking nateglinide only with meals and omitting it when a meal is skipped.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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