Drug interactions
Insulin isophane protamine human + Somapacitan
Severity: Moderate
Insulin isophane protamine human and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone analogs reduce insulin sensitivity and can raise blood glucose, particularly at higher doses. In patients on insulin, glycemic control may worsen after somapacitan is started, and insulin requirements may rise.
What this interaction means in plain words
Insulin isophane protamine human and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin isophane protamine human belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Growth hormone induces insulin resistance, antagonizing the glucose-lowering effect of insulin.
What to do
Monitor blood glucose more frequently when starting or adjusting somapacitan, and increase the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Insulin isophane protamine human with Somapacitan?
MediHelp rates the interaction as moderate. Insulin isophane protamine human and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone analogs reduce insulin sensitivity and can raise blood glucose, particularly at higher doses. In patients on insulin, glycemic control may worsen after somapacitan is started, and insulin requirements may rise.
How serious is the interaction between Insulin isophane protamine human and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or adjusting somapacitan, and increase the insulin dose as needed.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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