Drug interactions
Insulin isophane protamine human + Somatrogon
Severity: Moderate
Insulin isophane protamine human and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatrogon, a long-acting growth hormone, can reduce insulin sensitivity and raise glucose levels. Patients using NPH insulin may need higher doses to maintain control.
What this interaction means in plain words
Insulin isophane protamine human and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin isophane protamine human belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Growth hormone induces insulin resistance, antagonizing the glucose-lowering effect of insulin.
What to do
Check glucose more often after starting somatrogon or changing its dose, and titrate the insulin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Insulin isophane protamine human with Somatrogon?
MediHelp rates the interaction as moderate. Insulin isophane protamine human and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatrogon, a long-acting growth hormone, can reduce insulin sensitivity and raise glucose levels. Patients using NPH insulin may need higher doses to maintain control.
How serious is the interaction between Insulin isophane protamine human and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose more often after starting somatrogon or changing its dose, and titrate the insulin dose accordingly.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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