Drug interactions
Insulin lispro + Procarbazine
Severity: Moderate
Insulin lispro and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine is a weak monoamine oxidase inhibitor, and MAO inhibitors have been reported to enhance the hypoglycemic effect of insulin. The interaction is not well characterised for procarbazine specifically.
What this interaction means in plain words
Insulin lispro and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin lispro belongs to Endocrine; Procarbazine belongs to Oncology.
Why it happens
Not firmly established; MAO inhibition may enhance insulin secretion or sensitivity and impair counter-regulation.
What to do
Monitor blood glucose more often during procarbazine therapy and reduce the insulin dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Insulin lispro with Procarbazine?
MediHelp rates the interaction as moderate. Insulin lispro and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine is a weak monoamine oxidase inhibitor, and MAO inhibitors have been reported to enhance the hypoglycemic effect of insulin. The interaction is not well characterised for procarbazine specifically.
How serious is the interaction between Insulin lispro and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often during procarbazine therapy and reduce the insulin dose if hypoglycemia develops.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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