Drug interactions
Insulin neutral human + Tolazamide
Severity: Moderate
Insulin neutral human and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sulfonylurea with insulin gives additive glucose lowering and a higher risk of hypoglycemia. Dose adjustments are often needed.
What this interaction means in plain words
Insulin neutral human and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect: the sulfonylurea stimulates endogenous insulin secretion while exogenous insulin supplies insulin directly.
What to do
Monitor blood glucose and reduce the dose of the sulfonylurea or insulin if hypoglycemia occurs, especially in older patients or those with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Insulin neutral human with Tolazamide?
MediHelp rates the interaction as moderate. Insulin neutral human and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sulfonylurea with insulin gives additive glucose lowering and a higher risk of hypoglycemia. Dose adjustments are often needed.
How serious is the interaction between Insulin neutral human and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the dose of the sulfonylurea or insulin if hypoglycemia occurs, especially in older patients or those with renal impairment.
What other medicines interact with Insulin neutral human?
MediHelp also lists interactions of Insulin neutral human with, for example, Chlorpropamide, Ethanol, Mecasermin. The full list is on the Insulin neutral human page.
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