Drug interactions
Insulin neutral human + Tranylcypromine
Severity: Moderate
Insulin neutral human and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine, a non-selective MAO inhibitor, can potentiate the hypoglycemic effect of insulin, leading to unexpected or prolonged hypoglycemia.
What this interaction means in plain words
Insulin neutral human and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
The mechanism is not fully established; MAO inhibition may increase insulin sensitivity or secretion and impair counter-regulation.
What to do
Monitor blood glucose closely when tranylcypromine is started, changed or stopped, and reduce the insulin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin neutral human and Tranylcypromine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin neutral human
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Insulin neutral human with Tranylcypromine?
MediHelp rates the interaction as moderate. Insulin neutral human and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tranylcypromine, a non-selective MAO inhibitor, can potentiate the hypoglycemic effect of insulin, leading to unexpected or prolonged hypoglycemia.
How serious is the interaction between Insulin neutral human and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when tranylcypromine is started, changed or stopped, and reduce the insulin dose if needed.
What other medicines interact with Insulin neutral human?
MediHelp also lists interactions of Insulin neutral human with, for example, Chlorpropamide, Ethanol, Mecasermin. The full list is on the Insulin neutral human page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
