Drug interactions
Insulin neutral human-insulin isophane protamine human + Tolbutamide
Severity: Moderate
Insulin neutral human-insulin isophane protamine human and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolbutamide stimulates insulin secretion and adds to the effect of injected insulin, raising the risk of hypoglycemia. Dose adjustment is often required.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human-insulin isophane protamine human belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect of sulfonylurea-stimulated insulin secretion and exogenous insulin.
What to do
Monitor blood glucose closely and reduce the dose of either agent if hypoglycemia occurs. Teach hypoglycemia recognition and treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Tolbutamide?
MediHelp rates the interaction as moderate. Insulin neutral human-insulin isophane protamine human and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolbutamide stimulates insulin secretion and adds to the effect of injected insulin, raising the risk of hypoglycemia. Dose adjustment is often required.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the dose of either agent if hypoglycemia occurs. Teach hypoglycemia recognition and treatment.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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