Drug interactions
Insulin nph + Linezolid
Severity: Moderate
Insulin nph and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid has been associated with hypoglycemia in patients with diabetes receiving insulin or oral agents. Glucose-lowering may be greater than expected during therapy.
What this interaction means in plain words
Insulin nph and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism is not firmly established; MAO inhibition may enhance hypoglycemic effects.
What to do
Monitor blood glucose more frequently during linezolid therapy and reduce the insulin dose if hypoglycemia occurs. Educate patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Insulin nph with Linezolid?
MediHelp rates the interaction as moderate. Insulin nph and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid has been associated with hypoglycemia in patients with diabetes receiving insulin or oral agents. Glucose-lowering may be greater than expected during therapy.
How serious is the interaction between Insulin nph and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently during linezolid therapy and reduce the insulin dose if hypoglycemia occurs. Educate patient on hypoglycemia symptoms.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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