Drug interactions
Insulin nph + Procarbazine
Severity: Moderate
Insulin nph and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can enhance the glucose-lowering effect of insulin, and procarbazine has weak MAO inhibiting activity. This may result in unexpected or prolonged hypoglycemia in patients receiving insulin. The clinical evidence for procarbazine specifically is sparse.
What this interaction means in plain words
Insulin nph and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not well established; MAO inhibition may enhance insulin action or hypoglycemic response.
What to do
Monitor blood glucose more frequently when procarbazine is started or stopped. Reduce the insulin dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Insulin nph with Procarbazine?
MediHelp rates the interaction as moderate. Insulin nph and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can enhance the glucose-lowering effect of insulin, and procarbazine has weak MAO inhibiting activity. This may result in unexpected or prolonged hypoglycemia in patients receiving insulin. The clinical evidence for procarbazine specifically is sparse.
How serious is the interaction between Insulin nph and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when procarbazine is started or stopped. Reduce the insulin dose if hypoglycemia develops.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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