Drug interactions
Insulin nph + Tranylcypromine
Severity: Moderate
Insulin nph and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can potentiate the glucose-lowering effect of insulin, increasing hypoglycemia risk. The effect may be most noticeable during dose initiation or changes.
What this interaction means in plain words
Insulin nph and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blood glucose lowering; MAO inhibitors may enhance insulin sensitivity or hypoglycemic response.
What to do
Check blood glucose more often when tranylcypromine is started, adjusted or stopped. Reduce NPH insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Insulin nph with Tranylcypromine?
MediHelp rates the interaction as moderate. Insulin nph and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can potentiate the glucose-lowering effect of insulin, increasing hypoglycemia risk. The effect may be most noticeable during dose initiation or changes.
How serious is the interaction between Insulin nph and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often when tranylcypromine is started, adjusted or stopped. Reduce NPH insulin dose if hypoglycemia occurs.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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