Drug interactions
Insulin regular human + Maprotiline
Severity: Minor
Insulin regular human and Maprotiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants including maprotiline have occasionally been reported to alter glycemic control, and may enhance the glucose-lowering effect of insulin. Clinical relevance is usually small but hypoglycemia can occur in some patients.
What this interaction means in plain words
Insulin regular human and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible pharmacodynamic enhancement of insulin effect or altered glucose regulation; not well characterized.
What to do
Monitor blood glucose more often when maprotiline is started, changed or stopped. Adjust the insulin dose if glucose readings change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Insulin regular human with Maprotiline?
MediHelp rates the interaction as minor. Insulin regular human and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antidepressants including maprotiline have occasionally been reported to alter glycemic control, and may enhance the glucose-lowering effect of insulin. Clinical relevance is usually small but hypoglycemia can occur in some patients.
How serious is the interaction between Insulin regular human and Maprotiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when maprotiline is started, changed or stopped. Adjust the insulin dose if glucose readings change.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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