Drug interactions
Interferon alfa 2b + Ublituximab
Severity: Moderate
Interferon alfa 2b and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ublituximab depletes B cells and interferon alfa has immunomodulatory effects, so combined use may increase the risk of infection. Combined use is uncommon and clinical data are limited.
What this interaction means in plain words
Interferon alfa 2b and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Interferon alfa 2b belongs to Anti Virals; Ublituximab belongs to Miscellaneous.
Why it happens
Additive immunomodulatory and immunosuppressive effects: B-cell depletion with ublituximab plus interferon immune modulation.
What to do
Avoid starting both together unless clearly needed, and monitor for signs of infection; screen for hepatitis B before ublituximab as recommended.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Interferon alfa 2b
Other interactions of Ublituximab
Frequently asked questions
Can I take Interferon alfa 2b with Ublituximab?
MediHelp rates the interaction as moderate. Interferon alfa 2b and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ublituximab depletes B cells and interferon alfa has immunomodulatory effects, so combined use may increase the risk of infection. Combined use is uncommon and clinical data are limited.
How serious is the interaction between Interferon alfa 2b and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting both together unless clearly needed, and monitor for signs of infection; screen for hepatitis B before ublituximab as recommended.
What other medicines interact with Interferon alfa 2b?
MediHelp also lists interactions of Interferon alfa 2b with, for example, Deferiprone, Hydroxycarbamide, Pexidartinib. The full list is on the Interferon alfa 2b page.
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