Drug interactions
Interferon alfa 2b + Pretomanid
Severity: Major
Interferon alfa 2b and Pretomanid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The pretomanid-containing regimen is associated with hepatotoxicity, and interferon alfa 2b can also cause hepatic injury. Using them together may increase the likelihood of liver toxicity during tuberculosis treatment.
What this interaction means in plain words
Interferon alfa 2b and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Interferon alfa 2b belongs to Anti Virals; Pretomanid belongs to Anti Bacterial.
Why it happens
Additive hepatotoxicity from two agents that can each injure the liver.
What to do
Avoid combining where possible. If it is necessary, monitor liver function tests regularly and interrupt therapy when significant hepatic injury occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Interferon alfa 2b and Pretomanid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Interferon alfa 2b
Other interactions of Pretomanid
Frequently asked questions
Can I take Interferon alfa 2b with Pretomanid?
MediHelp rates the interaction as major. Interferon alfa 2b and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The pretomanid-containing regimen is associated with hepatotoxicity, and interferon alfa 2b can also cause hepatic injury. Using them together may increase the likelihood of liver toxicity during tuberculosis treatment.
How serious is the interaction between Interferon alfa 2b and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If it is necessary, monitor liver function tests regularly and interrupt therapy when significant hepatic injury occurs.
What other medicines interact with Interferon alfa 2b?
MediHelp also lists interactions of Interferon alfa 2b with, for example, Deferiprone, Hydroxyurea, Pexidartinib. The full list is on the Interferon alfa 2b page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
