Drug interactions
Interferon alfa n3 + Warfarin
Severity: Moderate
Interferon alfa n3 and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Interferons can alter hepatic drug metabolism and have been associated with increased INR in patients taking warfarin. Interferon-related thrombocytopenia may also add to bleeding risk.
What this interaction means in plain words
Interferon alfa n3 and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable suppression of CYP-mediated metabolism by interferon and possible effects on platelets; not fully established.
What to do
Check INR more often when starting, changing or stopping interferon, and adjust the warfarin dose accordingly. Monitor the platelet count.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Interferon alfa n3 with Warfarin?
MediHelp rates the interaction as moderate. Interferon alfa n3 and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Interferons can alter hepatic drug metabolism and have been associated with increased INR in patients taking warfarin. Interferon-related thrombocytopenia may also add to bleeding risk.
How serious is the interaction between Interferon alfa n3 and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR more often when starting, changing or stopping interferon, and adjust the warfarin dose accordingly. Monitor the platelet count.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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