Drug interactions
Interferon beta 1a + Pexidartinib
Severity: Major
Interferon beta 1a and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury. Interferon beta can also raise liver enzymes and occasionally cause hepatic injury. Together, the risk of hepatotoxicity may be increased.
What this interaction means in plain words
Interferon beta 1a and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Interferon beta 1a belongs to Central Nervous System; Pexidartinib belongs to Oncology.
Why it happens
Additive hepatotoxicity from two agents that can each cause liver injury.
What to do
Avoid coadministration where possible. If both are needed, monitor liver tests frequently and stop pexidartinib or interferon if significant liver injury occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Interferon beta 1a and Pexidartinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Interferon beta 1a
Other interactions of Pexidartinib
Frequently asked questions
Can I take Interferon beta 1a with Pexidartinib?
MediHelp rates the interaction as major. Interferon beta 1a and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury. Interferon beta can also raise liver enzymes and occasionally cause hepatic injury. Together, the risk of hepatotoxicity may be increased.
How serious is the interaction between Interferon beta 1a and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible. If both are needed, monitor liver tests frequently and stop pexidartinib or interferon if significant liver injury occurs.
What other medicines interact with Interferon beta 1a?
MediHelp also lists interactions of Interferon beta 1a with, for example, Deferiprone, Etrasimod, Hydroxyurea. The full list is on the Interferon beta 1a page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
