Drug interactions
Iobenguane i + Linezolid
Severity: Moderate
Iobenguane i and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iobenguane is taken up into cells via the norepinephrine transporter, and drugs that interfere with catecholamine uptake or storage can reduce tumor uptake and efficacy. Linezolid is listed among the drugs to avoid, but its effect on uptake is theoretical.
What this interaction means in plain words
Iobenguane i and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible interference with catecholamine handling reduces iobenguane uptake; the mechanism for linezolid is predicted rather than established.
What to do
Where clinically possible, stop linezolid for at least five half-lives before iobenguane dosimetry or treatment. Do not restart it until at least 7 days after each iobenguane dose, or choose an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Iobenguane i with Linezolid?
MediHelp rates the interaction as moderate. Iobenguane i and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iobenguane is taken up into cells via the norepinephrine transporter, and drugs that interfere with catecholamine uptake or storage can reduce tumor uptake and efficacy. Linezolid is listed among the drugs to avoid, but its effect on uptake is theoretical.
How serious is the interaction between Iobenguane i and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where clinically possible, stop linezolid for at least five half-lives before iobenguane dosimetry or treatment. Do not restart it until at least 7 days after each iobenguane dose, or choose an alternative antibiotic.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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