Drug interactions
Iobenguane i + Maprotiline
Severity: Major
Iobenguane i and Maprotiline: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline blocks the norepinephrine transporter that is responsible for cellular uptake of iobenguane. This can reduce tumour and myocardial uptake of the radiotracer and lead to false-negative scans.
What this interaction means in plain words
Iobenguane i and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of the norepinephrine transporter reduces uptake of iobenguane into adrenergic tissue.
What to do
If clinically feasible, stop maprotiline for an adequate washout period (at least five half-lives, which is long for maprotiline) before imaging or therapy. Coordinate the withdrawal with the prescriber and watch for relapse of the psychiatric condition.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Iobenguane i with Maprotiline?
MediHelp rates the interaction as major. Iobenguane i and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Maprotiline blocks the norepinephrine transporter that is responsible for cellular uptake of iobenguane. This can reduce tumour and myocardial uptake of the radiotracer and lead to false-negative scans.
How serious is the interaction between Iobenguane i and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If clinically feasible, stop maprotiline for an adequate washout period (at least five half-lives, which is long for maprotiline) before imaging or therapy. Coordinate the withdrawal with the prescriber and watch for relapse of the psychiatric condition.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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