Drug interactions
Iobenguane i + Nadolol
Severity: Moderate
Iobenguane i and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drugs affecting catecholamine uptake or storage can reduce uptake of iobenguane into target tissue and lower its efficacy. Beta-blockers are listed among agents that may interfere, though their mechanism is less direct.
What this interaction means in plain words
Iobenguane i and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Interference with norepinephrine transporter-mediated uptake or catecholamine handling may reduce iobenguane uptake; mechanism for nadolol is not well established.
What to do
Follow iobenguane labeling by stopping interfering drugs for at least 5 half-lives before dosing and not resuming until at least 7 days after each dose. Arrange alternative blood pressure control during this window.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
Frequently asked questions
Can I take Iobenguane i with Nadolol?
MediHelp rates the interaction as moderate. Iobenguane i and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drugs affecting catecholamine uptake or storage can reduce uptake of iobenguane into target tissue and lower its efficacy. Beta-blockers are listed among agents that may interfere, though their mechanism is less direct.
How serious is the interaction between Iobenguane i and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow iobenguane labeling by stopping interfering drugs for at least 5 half-lives before dosing and not resuming until at least 7 days after each dose. Arrange alternative blood pressure control during this window.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Amifostine. The full list is on the Nadolol page.
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