Drug interactions
Iobenguane i + Tranylcypromine
Severity: Major
Iobenguane i and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iobenguane enters cells through the norepinephrine transporter, and drugs that deplete catecholamine stores or interfere with uptake can reduce its uptake into target tissue. This may lessen diagnostic accuracy or therapeutic efficacy of iobenguane I-131.
What this interaction means in plain words
Iobenguane i and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibitors alter catecholamine storage and handling, which may interfere with norepinephrine-transporter-mediated uptake of iobenguane.
What to do
Stop tranylcypromine for at least five half-lives before iobenguane dosimetry or therapy, and do not restart until at least 7 days after each dose, as the prescribing information advises. Arrange psychiatric supervision for the interruption.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Iobenguane i with Tranylcypromine?
MediHelp rates the interaction as major. Iobenguane i and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iobenguane enters cells through the norepinephrine transporter, and drugs that deplete catecholamine stores or interfere with uptake can reduce its uptake into target tissue. This may lessen diagnostic accuracy or therapeutic efficacy of iobenguane I-131.
How serious is the interaction between Iobenguane i and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop tranylcypromine for at least five half-lives before iobenguane dosimetry or therapy, and do not restart until at least 7 days after each dose, as the prescribing information advises. Arrange psychiatric supervision for the interruption.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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