Drug interactions
Iopromide + Linagliptin-metformin
Severity: Major
Iopromide and Linagliptin-metformin: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravascular iopromide can cause acute kidney injury, which impairs metformin elimination. This raises the risk of lactic acidosis, particularly with low eGFR or intra-arterial administration.
What this interaction means in plain words
Iopromide and Linagliptin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Contrast-induced decline in renal function reduces metformin clearance and allows accumulation.
What to do
Hold metformin at the time of or before the procedure if eGFR is below 30, acute kidney injury is present, or contrast is intra-arterial. Re-evaluate renal function about 48 hours later before restarting.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Linagliptin-metformin
Frequently asked questions
Can I take Iopromide with Linagliptin-metformin?
MediHelp rates the interaction as major. Iopromide and Linagliptin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravascular iopromide can cause acute kidney injury, which impairs metformin elimination. This raises the risk of lactic acidosis, particularly with low eGFR or intra-arterial administration.
How serious is the interaction between Iopromide and Linagliptin-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin at the time of or before the procedure if eGFR is below 30, acute kidney injury is present, or contrast is intra-arterial. Re-evaluate renal function about 48 hours later before restarting.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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