Drug interactions
Ioversol + Vancomycin
Severity: Moderate
Ioversol and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast media can cause contrast-associated acute kidney injury, and vancomycin is also nephrotoxic. Giving both increases the risk of renal impairment, especially in patients with existing kidney disease, dehydration or other nephrotoxins.
What this interaction means in plain words
Ioversol and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity through contrast-induced tubular injury and vancomycin tubular toxicity.
What to do
Ensure adequate hydration and monitor serum creatinine for several days after contrast. Adjust vancomycin dosing by trough or AUC levels and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Ioversol with Vancomycin?
MediHelp rates the interaction as moderate. Ioversol and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iodinated contrast media can cause contrast-associated acute kidney injury, and vancomycin is also nephrotoxic. Giving both increases the risk of renal impairment, especially in patients with existing kidney disease, dehydration or other nephrotoxins.
How serious is the interaction between Ioversol and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor serum creatinine for several days after contrast. Adjust vancomycin dosing by trough or AUC levels and renal function.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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