Drug interactions
Ioxilan + Saxagliptin-metformin
Severity: Moderate
Ioxilan and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravascular ioxilan can cause acute kidney injury, and reduced renal function impairs metformin elimination. Metformin accumulation may lead to lactic acidosis, which is rare but life-threatening.
What this interaction means in plain words
Ioxilan and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Contrast-induced decline in renal function reduces metformin clearance, raising the risk of metformin accumulation and lactic acidosis.
What to do
Withhold metformin at the time of or before contrast in patients with eGFR below 30, acute kidney injury, or intra-arterial administration. Re-check renal function about 48 hours later and resume metformin only if it is stable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Ioxilan with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Ioxilan and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravascular ioxilan can cause acute kidney injury, and reduced renal function impairs metformin elimination. Metformin accumulation may lead to lactic acidosis, which is rare but life-threatening.
How serious is the interaction between Ioxilan and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold metformin at the time of or before contrast in patients with eGFR below 30, acute kidney injury, or intra-arterial administration. Re-check renal function about 48 hours later and resume metformin only if it is stable.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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