Drug interactions
Ipratropium-salbutamol + Lofepramine
Severity: Moderate
Ipratropium-salbutamol and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of salbutamol, causing tachycardia or arrhythmias. Lofepramine has weaker anticholinergic activity than older tricyclics.
What this interaction means in plain words
Ipratropium-salbutamol and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclic inhibition of norepinephrine reuptake, increasing adrenergic stimulation.
What to do
Monitor heart rate and blood pressure, and reduce the beta-agonist dose if cardiovascular effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ipratropium-salbutamol and Lofepramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ipratropium-salbutamol
Frequently asked questions
Can I take Ipratropium-salbutamol with Lofepramine?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of salbutamol, causing tachycardia or arrhythmias. Lofepramine has weaker anticholinergic activity than older tricyclics.
How serious is the interaction between Ipratropium-salbutamol and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and reduce the beta-agonist dose if cardiovascular effects appear.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
