Drug interactions
Ipratropium-salbutamol + Phenoxybenzamine
Severity: Moderate
Ipratropium-salbutamol and Phenoxybenzamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine is an irreversible alpha-blocker. Salbutamol causes beta-2 vasodilation and may produce reflex tachycardia, so with alpha blockade it can exaggerate hypotension and tachycardia.
What this interaction means in plain words
Ipratropium-salbutamol and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Unopposed beta-2 mediated vasodilation on top of alpha-adrenergic blockade, with reflex tachycardia.
What to do
Monitor blood pressure and heart rate, especially with nebulized or high-dose salbutamol. Advise patients to rise slowly and reduce salbutamol dosing if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Frequently asked questions
Can I take Ipratropium-salbutamol with Phenoxybenzamine?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine is an irreversible alpha-blocker. Salbutamol causes beta-2 vasodilation and may produce reflex tachycardia, so with alpha blockade it can exaggerate hypotension and tachycardia.
How serious is the interaction between Ipratropium-salbutamol and Phenoxybenzamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, especially with nebulized or high-dose salbutamol. Advise patients to rise slowly and reduce salbutamol dosing if symptomatic hypotension occurs.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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