Drug interactions
Ipratropium-salbutamol + Romidepsin
Severity: Moderate
Ipratropium-salbutamol and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin has been associated with ECG changes including QT prolongation. Salbutamol may add to arrhythmia risk through hypokalemia and tachycardia.
What this interaction means in plain words
Ipratropium-salbutamol and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation with beta-2 agonist-induced hypokalemia.
What to do
Monitor ECG and keep potassium and magnesium within normal range during romidepsin therapy. Limit high-dose salbutamol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Frequently asked questions
Can I take Ipratropium-salbutamol with Romidepsin?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin has been associated with ECG changes including QT prolongation. Salbutamol may add to arrhythmia risk through hypokalemia and tachycardia.
How serious is the interaction between Ipratropium-salbutamol and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium and magnesium within normal range during romidepsin therapy. Limit high-dose salbutamol use.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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