Drug interactions
Ipratropium-salbutamol + Terbutaline
Severity: Moderate
Ipratropium-salbutamol and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using salbutamol together with terbutaline duplicates beta2-agonist therapy and increases the risk of tachycardia, tremor, palpitations and hypokalemia. It provides little added bronchodilation and can raise the risk of arrhythmia.
What this interaction means in plain words
Ipratropium-salbutamol and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Terbutaline belongs to Respiratory.
Why it happens
Additive beta2-adrenergic stimulation causing cardiovascular effects and intracellular potassium shift.
What to do
Avoid concurrent use of two short-acting beta-agonists; choose one agent. If both are unavoidable, monitor heart rate and serum potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Terbutaline
Frequently asked questions
Can I take Ipratropium-salbutamol with Terbutaline?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using salbutamol together with terbutaline duplicates beta2-agonist therapy and increases the risk of tachycardia, tremor, palpitations and hypokalemia. It provides little added bronchodilation and can raise the risk of arrhythmia.
How serious is the interaction between Ipratropium-salbutamol and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two short-acting beta-agonists; choose one agent. If both are unavoidable, monitor heart rate and serum potassium.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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