Drug interactions
Ipratropium-salbutamol + Umeclidinium bromide
Severity: Moderate
Ipratropium-salbutamol and Umeclidinium bromide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Umeclidinium is a long-acting inhaled antimuscarinic, and combining it with ipratropium duplicates therapy. This may increase anticholinergic effects such as dry mouth, urinary retention, and worsening of narrow-angle glaucoma.
What this interaction means in plain words
Ipratropium-salbutamol and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects from duplicate inhaled anticholinergic therapy.
What to do
Avoid concurrent use of ipratropium with umeclidinium and choose a single antimuscarinic. Use salbutamol alone as the rescue agent if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ipratropium-salbutamol and Umeclidinium bromide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ipratropium-salbutamol
Frequently asked questions
Can I take Ipratropium-salbutamol with Umeclidinium bromide?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Umeclidinium is a long-acting inhaled antimuscarinic, and combining it with ipratropium duplicates therapy. This may increase anticholinergic effects such as dry mouth, urinary retention, and worsening of narrow-angle glaucoma.
How serious is the interaction between Ipratropium-salbutamol and Umeclidinium bromide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of ipratropium with umeclidinium and choose a single antimuscarinic. Use salbutamol alone as the rescue agent if needed.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
