Drug interactions
Iptacopan + Rifampicin
Severity: Moderate
Iptacopan and Rifampicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin induces CYP2C8 and other enzymes and may reduce iptacopan exposure. Lower levels could reduce complement inhibition and disease control.
What this interaction means in plain words
Iptacopan and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iptacopan belongs to Miscellaneous; Rifampicin belongs to Anti Bacterial.
Why it happens
Induction of CYP2C8 (and possibly UGTs and transporters) by rifampicin increases iptacopan clearance.
What to do
Monitor clinical response and hemolysis or proteinuria markers. Consider an alternative to rifampicin if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Iptacopan and Rifampicin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Iptacopan
- Carbamazepine + Iptacopan Moderate
- Gemfibrozil + Iptacopan Moderate
- Iptacopan + Phenytoin Moderate
- Iptacopan + Secobarbital Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Iptacopan with Rifampicin?
MediHelp rates the interaction as moderate. Iptacopan and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin induces CYP2C8 and other enzymes and may reduce iptacopan exposure. Lower levels could reduce complement inhibition and disease control.
How serious is the interaction between Iptacopan and Rifampicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and hemolysis or proteinuria markers. Consider an alternative to rifampicin if efficacy declines.
What other medicines interact with Iptacopan?
MediHelp also lists interactions of Iptacopan with, for example, Carbamazepine, Gemfibrozil, Phenytoin. The full list is on the Iptacopan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
