Drug interactions
Delamanid + Rifampicin
Severity: Contraindicated
Delamanid and Rifampicin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin lowers delamanid exposure, with a reduction shown in pharmacokinetic studies. Lower levels may reduce efficacy in drug-resistant TB.
What this interaction means in plain words
Delamanid and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Delamanid belongs to Anti Bacterial; Rifampicin belongs to Anti Bacterial.
Why it happens
Rifampicin induces CYP3A4 and other enzymes, accelerating delamanid clearance.
What to do
Do not co-administer; rifampicin is typically not part of regimens for rifampicin-resistant TB requiring delamanid.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Delamanid
- Carbamazepine + Delamanid Contraindicated
- Delamanid + Moxifloxacin Major
- Delamanid + Ritonavir Major
- Delamanid + Ethambutol Minor
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
- Isavuconazonium + Rifampicin Contraindicated
Frequently asked questions
Can I take Delamanid with Rifampicin?
MediHelp rates the interaction as contraindicated. Delamanid and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifampicin lowers delamanid exposure, with a reduction shown in pharmacokinetic studies. Lower levels may reduce efficacy in drug-resistant TB.
How serious is the interaction between Delamanid and Rifampicin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; rifampicin is typically not part of regimens for rifampicin-resistant TB requiring delamanid.
What other medicines interact with Delamanid?
MediHelp also lists interactions of Delamanid with, for example, Carbamazepine, Moxifloxacin, Ritonavir. The full list is on the Delamanid page.
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