Drug interactions
Irbesartan + Parecoxib
Severity: Moderate
Irbesartan and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
As an NSAID, parecoxib (via valdecoxib) can reduce the antihypertensive effect of irbesartan. The combination increases the risk of renal impairment and hyperkalemia, especially in older or volume-depleted patients.
What this interaction means in plain words
Irbesartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion, compounded by angiotensin receptor blockade.
What to do
Ensure hydration and use the shortest course possible. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Parecoxib?
MediHelp rates the interaction as moderate. Irbesartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. As an NSAID, parecoxib (via valdecoxib) can reduce the antihypertensive effect of irbesartan. The combination increases the risk of renal impairment and hyperkalemia, especially in older or volume-depleted patients.
How serious is the interaction between Irbesartan and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure hydration and use the shortest course possible. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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