Drug interactions
Irbesartan + Penbutolol
Severity: Minor
Irbesartan and Penbutolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure and are often used together, but the combined effect may cause excessive hypotension or bradycardia. Beta-blockers can also slightly raise potassium.
What this interaction means in plain words
Irbesartan and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antihypertensive effects through beta-blockade and angiotensin receptor blockade.
What to do
Monitor blood pressure and heart rate. Check potassium in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Penbutolol?
MediHelp rates the interaction as minor. Irbesartan and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs lower blood pressure and are often used together, but the combined effect may cause excessive hypotension or bradycardia. Beta-blockers can also slightly raise potassium.
How serious is the interaction between Irbesartan and Penbutolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate. Check potassium in patients with renal impairment.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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